Andrew Yen Selected Research

Tretinoin (Retinoic Acid)

12/2021	Evidence of off-target effects of bosutinib that promote retinoic acid-induced differentiation of non-APL AML cells.
1/2020	Dissecting the novel partners of nuclear c-Raf and its role in all-trans retinoic acid (ATRA)-induced myeloblastic leukemia cells differentiation.
1/2020	Roscovitine enhances All-trans retinoic acid (ATRA)-induced leukemia cell differentiation: Novel effects on signaling molecules for a putative Cdk2 inhibitor.
1/2019	Retinoic acid and 6-formylindolo(3,2-b)carbazole (FICZ) combination therapy reveals putative targets for enhancing response in non-APL AML.
12/2018	Src family kinase inhibitor bosutinib enhances retinoic acid-induced differentiation of HL-60 leukemia cells.
12/2018	CXCR5 overexpression in HL-60 cells enhances chemotaxis toward CXCL13 without anticipated interaction partners or enhanced MAPK signaling.
1/2016	RRD-251 enhances all-trans retinoic acid (RA)-induced differentiation of HL-60 myeloblastic leukemia cells.
8/2015	GW5074 and PP2 kinase inhibitors implicate nontraditional c-Raf and Lyn function as drivers of retinoic acid-induced maturation.
1/2015	6-Formylindolo(3,2-b)Carbazole (FICZ) Modulates the Signalsome Responsible for RA-Induced Differentiation of HL-60 Myeloblastic Leukemia Cells.
1/2015	The AhR agonist VAF347 augments retinoic acid-induced differentiation in leukemia cells.

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Andrew Yen Research Topics

Disease

30	Leukemia 12/2021 - 05/2002
8	Neoplasms (Cancer) 01/2020 - 03/2004
8	Acute Promyelocytic Leukemia 01/2020 - 12/2004
6	Myeloid Leukemia (Leukemia, Myelocytic) 12/2021 - 09/2010
5	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2020 - 01/2014
5	Chronic Obstructive Pulmonary Disease (COPD) 01/2020 - 01/2016
3	Retinoblastoma (Glioblastoma, Retinal) 01/2016 - 12/2004
2	Chronic Bronchitis 01/2020 - 01/2016
2	Genomic Instability 08/2010 - 09/2006
1	Hyperplasia 01/2021
1	Emphysema 01/2020
1	Obstructive Lung Diseases (Obstructive Lung Disease) 11/2019
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2018
1	Hypoxia (Hypoxemia) 10/2016
1	Tuberculosis (Tuberculoses) 10/2016
1	Pulmonary Tuberculosis 10/2016
1	Inflammation (Inflammations) 08/2015
1	Carcinogenesis 08/2015
1	Chronic Disease (Chronic Diseases) 08/2015
1	Vascular Diseases (Vascular Disease) 08/2015
1	Breast Neoplasms (Breast Cancer) 07/2015
1	Immunoglobulin G4-Related Disease 01/2015
1	Pain (Aches) 07/2012
1	Lymphoma (Lymphomas) 12/2011
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 08/2006

Drug/Important Bio-Agent (IBA)

34	Tretinoin (Retinoic Acid)FDA LinkGeneric 12/2021 - 05/2002
4	Proteins (Proteins, Gene)FDA Link 08/2006 - 07/2004
3	GoldIBA 11/2019 - 01/2016
3	Transcription Factors (Transcription Factor)IBA 01/2015 - 03/2011
3	Mitogen-Activated Protein KinasesIBA 12/2011 - 11/2008
2	bosutinibIBA 12/2021 - 12/2018
2	src-Family KinasesIBA 12/2018 - 08/2015
2	RRD 251IBA 02/2018 - 01/2016
2	Phosphotransferases (Kinase)IBA 08/2015 - 09/2006
2	6-formylindolo(3,2-b)carbazoleIBA 01/2015 - 05/2013
2	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 01/2015 - 03/2011
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 12/2011 - 08/2010
2	Tumor Viral Antigens (Large T Antigen)IBA 07/2004 - 07/2004
2	Bromodeoxyuridine (BrdU)IBA 07/2004 - 07/2004
1	RoscovitineIBA 01/2020
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 01/2020
1	Phenobarbital (Luminal)FDA Link 01/2020
1	Vitamin D FDA LinkGeneric 02/2018
1	CalciumIBA 01/2018
1	AcidsIBA 10/2016
1	Interleukin-10 (Interleukin 10)IBA 10/2016
1	Carbon MonoxideIBA 10/2016
1	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 01/2016
1	RetinoidsIBA 12/2015
1	5- iodo- 3- ((3,5- dibromo- 4- hydroxyphenyl)methylene)- 2- indolinoneIBA 08/2015
1	ResveratrolIBA 08/2015
1	CollagenIBA 07/2015
1	Immunoglobulins (Immunoglobulin)IBA 01/2015
1	VAF347IBA 01/2015
1	AntigensIBA 07/2014
1	4- ethoxymethylene- 2- phenyl- 2- oxazoline- 5- one (phOx)IBA 01/2013
1	AG 1879IBA 01/2013
1	InterferonsIBA 12/2011
1	MitogensIBA 12/2011
1	Interferon Regulatory Factor-1 (Interferon Regulatory Factor 1)IBA 12/2011
1	Therapeutic UsesIBA 03/2011
1	Stem Cell FactorIBA 03/2011
1	Arsenic Trioxide (Trisenox)FDA Link 09/2010
1	promyelocytic leukemia-retinoic acid receptor alpha fusion oncoproteinIBA 09/2010
1	Niacinamide (Nicotinamide)FDA LinkGeneric 01/2009
1	AmidesIBA 01/2009
1	1,25-dihydroxyvitamin DIBA 01/2009
1	Vitamin A (Retinol)FDA LinkGeneric 01/2009
1	Estrogen ReceptorsIBA 10/2008
1	Estrogens (Estrogen)FDA Link 10/2008
1	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 08/2007
1	Cholecalciferol (Vitamin D3)FDA Link 08/2007
1	Calcitriol (Calcijex)FDA LinkGeneric 08/2006
1	Retinoblastoma ProteinIBA 12/2004
1	Conditioned Culture MediaIBA 12/2004
1	Antineoplastic Agents (Antineoplastics)IBA 12/2004
1	retinoic acid receptor betaIBA 12/2004
1	ProdrugsIBA 12/2004
1	LigandsIBA 12/2004
1	tazarotene (Tazorac)FDA Link 12/2004
1	Retinoid X Receptors (Retinoid X Receptor)IBA 12/2004
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 12/2004

Therapy/Procedure

11	Therapeutics 01/2020 - 12/2004
1	Stents 01/2021
1	Endoscopes 07/2012
1	Drug Therapy (Chemotherapy) 03/2004